Research links variations in the gene GRIN2A to a higher risk of developing schizophrenia and other forms of mental illness. A team of physicians specializing in genetics and neurology discovered that mental illnesses such as schizophrenia are closely linked to mutations in the GRIN2A gene. The scientists mantain that identifying this genetic risk factor opens up the possibility of designing preventive therapies in the future. The GRIN2A gene regulates communication between neurons by producing the GluN2A protein. When functioning optimally, it promotes the transmission of electrical signals between nerve cells and facilitates essential processes such as learning, memory, language, and brain development.

This paper presents a chatbot-based system to engage young Spanish people in the awareness of certain mental disorders through a self-disclosure technique. The study was carried out in a population of teenagers aged between 12 and 18 years. The dialogue engine mixes closed and open conversations, so certain controlled messages are sent to focus the chat on a specific disorder, which will change over time. Once a set of trial questions is answered, the system can initiate the conversation on the disorder under the focus according to the user's sensibility to that disorder, in an attempt to establish a more empathetic communication. Then, an open conversation based on the GPT-3 language model is initiated, allowing the user to express themselves with more freedom. The results show that these systems are of interest to young people and could help them become aware of certain mental disorders.

Depression is the most common mental health disorder, and its prevalence increased during the COVID-19 pandemic. As one of the most extensively researched psychological conditions, recent research has increasingly focused on leveraging social media data to enhance traditional methods of depression screening. This paper addresses the growing interest in interdisciplinary research on depression, and aims to support early-career researchers by providing a comprehensive and up-to-date list of datasets for analyzing and predicting depression through social media data. We present an overview of datasets published between 2019 and 2024. We also make the comprehensive list of datasets available online as a continuously updated resource, with the hope that it will facilitate further interdisciplinary research into the linguistic expressions of depression on social media.

Analyzing functional brain networks using functional magnetic resonance imaging (fMRI) is crucial for understanding psychiatric disorders and addictive behaviors. While existing fMRI-based graph convolutional networks (GCNs) show considerable promise for feature extraction, they often fall short in characterizing complex relationships between brain regions and demographic factors and accounting for interpretable variables linked to psychiatric conditions. We propose NeuroTree to overcome these limitations, integrating a k-hop AGE-GCN with neural ordinary differential equations (ODEs). This framework leverages an attention mechanism to optimize functional connectivity (FC), thereby enhancing dynamic FC feature learning for brain disease classification. Furthermore, NeuroTree effectively decodes fMRI network features into tree structures, which improves the capture of high-order brain regional pathway features and enables the identification of hierarchical neural behavioral patterns essential for understanding disease-related brain subnetworks. Our empirical evaluations demonstrate that NeuroTree achieves state-of-the-art performance across two distinct mental disorder datasets and provides valuable insights into age-related deterioration patterns. These findings underscore the model's efficacy in predicting psychiatric disorders and elucidating their underlying neural mechanisms.

In psychological practice, standardized questionnaires serve as essential tools for assessing mental constructs (e.g., attitudes, traits, and emotions) through structured questions (aka items). With the increasing prevalence of social media platforms where users share personal experiences and emotions, researchers are exploring computational methods to leverage this data for rapid mental health screening. In this study, we propose a novel adaptive Retrieval-Augmented Generation (RAG) approach that completes psychological questionnaires by analyzing social media posts. Our method retrieves the most relevant user posts for each question in a psychological survey and uses Large Language Models (LLMs) to predict questionnaire scores in a zero-shot setting. Our findings are twofold. First we demonstrate that this approach can effectively predict users' responses to psychological questionnaires, such as the Beck Depression Inventory II (BDI-II), achieving performance comparable to or surpassing state-of-the-art models on Reddit-based benchmark datasets without relying on training data. Second, we show how this methodology can be generalized as a scalable screening tool, as the final assessment is systematically derived by completing standardized questionnaires and tracking how individual item responses contribute to the diagnosis, aligning with established psychometric practices.

The increasing demand for mental health services has highlighted the need for innovative solutions, particularly in the realm of psychological conversational AI, where the availability of sensitive data is scarce. In this work, we explored the development of a system tailored for mental health support with a novel approach to psychological assessment based on explainable emotional profiles in combination with empathetic conversational models, offering a promising tool for augmenting traditional care, particularly where immediate expertise is unavailable. Our work can be divided into two main parts, intrinsecaly connected to each other. First, we present RACLETTE, a conversational system that demonstrates superior emotional accuracy compared to state-of-the-art benchmarks in both understanding users' emotional states and generating empathetic responses during conversations, while progressively building an emotional profile of the user through their interactions. Second, we show how the emotional profiles of a user can be used as interpretable markers for mental health assessment. These profiles can be compared with characteristic emotional patterns associated with different mental disorders, providing a novel approach to preliminary screening and support.

For the early identification, diagnosis, and treatment of mental health illnesses, the integration of deep learning (DL) and machine learning (ML) has started playing a significant role. By evaluating complex data from imaging, genetics, and behavioral assessments, these technologies have the potential to significantly improve clinical outcomes. However, they also present unique challenges related to data integration and ethical issues. This survey reviews the development of ML and DL methods for the early diagnosis and treatment of mental health issues. It examines a range of applications, with a particular emphasis on behavioral assessments, genetic and biomarker analysis, and medical imaging for diagnosing diseases like depression, bipolar disorder, and schizophrenia. Predictive modeling for illness progression is further discussed, focusing on the role of risk prediction models and longitudinal studies. Key findings highlight how ML and DL can improve diagnostic accuracy and treatment outcomes while addressing methodological inconsistencies, data integration challenges, and ethical concerns. The study emphasizes the importance of building real-time monitoring systems for individualized treatment, enhancing data fusion techniques, and fostering interdisciplinary collaboration. Future research should focus on overcoming these obstacles to ensure the valuable and ethical application of ML and DL in mental health services.

Mental disorders pose a global challenge, aggravated by the shortage of qualified mental health professionals. Mental disorder prediction from social media posts by current LLMs is challenging due to the complexities of sequential text data and the limited context length of language models. Current language model-based approaches split a single data instance into multiple chunks to compensate for limited context size. The predictive model is then applied to each chunk individually, and the most voted output is selected as the final prediction. This results in the loss of inter-post dependencies and important time variant information, leading to poor performance. We propose a novel framework which first compresses the large sequence of chronologically ordered social media posts into a series of numbers. We then use this time variant representation for mental disorder classification. We demonstrate the generalization capabilities of our framework by outperforming the current SOTA in three different mental conditions: depression, self-harm, and anorexia, with an absolute improvement of 5% in the F1 score. We investigate the situation where current data instances fall within the context length of language models and present empirical results highlighting the importance of temporal properties of textual data. Furthermore, we utilize the proposed framework for a cross-domain study, exploring commonalities across disorders and the possibility of inter-domain data usage.